3-丁炔-1-醇的合成方法研究

Study on New Synthesis Methods of 3-Butynol

介绍了制备的低温金属有机合成法、格氏试剂法和四氢呋喃开环法及其优缺点。采用1种新方法将四氢呋喃开环法中副产物多、产率低的光催化氯代自由基反应设计为原子经济性为100%的加成反应,即以二氢呋喃为原料与氯经加成反应生成二氯二氢呋喃,经消除和开环消除得到3-丁炔-1-醇。实验结果表明,该法中的二氢呋喃氯加成反应收率92.4%。提高了反应的总产率,减少了污染物的产生量,可适于产业化。

Synthetic routes of 3-butyn-1-ol, grignard reaction, ring opening of tetrahydrofuran and their advantages and disadvantages are compared. A new method is used to change photo catalysis free radical reaction in the ring opening of tetrahydropyrrole into addition reaction, i.e., dichlorodihydrofuran is produced through addition of dihydrofuran and chlorine, elimination and ring opening elimination to get 3-butyn-1-ol. Experiments can see addition reaction yield of dihydrofuran in this method is 2.4%. Total yield is raised and total output of pollutants is reduced.