用“代际-脑-经验模型”理解边缘性人格障碍的病理机制

Understanding the Pathogenesis of Borderline Personality Disorder Using the Intergenerational Brain-and-Experience Model

边缘性人格障碍(Borderlinepersonalitydisorder,BPD)在西方是一种常见的人格障碍,而在中国大陆没有进入CCMD诊断系统,因此缺乏相应的研究。本文将对BPD的临床现象学内容进行回顾和澄清,并在国外有关研究BPD的脑神经科学、神经生化学和发展心理病理学研究进展的基础上,建立了“代际—脑—经验模型”(Intergenera-tionalBrain-and-ExperienceModel,IBEM),并以之为线索探讨BPD的病理机制,以期深入理解BPD作为一种人格障碍的独特性,最后对在我国大陆开展BPD的研究方向进行了探讨。

Borderline personality disorder （BPD） is very. common among psychiatric patients in the West. The CCMD-3 （Chinese Classification of Mental Disorders, Version three）, however, does not contain the BPD diagnosis, and few systematic studies have been conducted to explore the construct validity and prevalence of BPD in China. In this review, we first review the empirical evidence related to BPD. Moreover, an Intergenerational Brain-and-Experience Model is proposed to help clinicians to understand the pathogenesis of BPD. Future directions of BPD research in China are also discussed.