摘要
目的研究决明子降血脂的有效部位。方法采用系统溶剂提取法对决明子进行分部位提取,制得决明子提取物。建立小鼠高脂血症模型,对各提取物进行降血脂药效学研究,确定决明子降血脂有效部位。结果决明子正丁醇提取物具有明显的降血脂作用,能显著降低高脂血症小鼠血清总胆固醇(TC)和甘油三酯(TG)。结论正丁醇提取物为决明子降血脂有效部位。
Objective To study the effective part of reducing blood lipid in Semen Cassiae. Methods The extracts of Semen Cassia were processed by dissolvent subsection -extracting, and then adopt hyperlipidemia model by mice to study the pharmacological effect of the different extracts from Semen Cassiae. Results The n- BuOH extracts have obvious action of reducing blood lipid. It can notably lower total cholesterin (TC)and glycerinum( TG ) in serum from mice of hyperlipidemia. Conclusion n-BuOH extracts is the active part of reducing blood lipid in Semen Cassiae.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第6期904-905,共2页
Lishizhen Medicine and Materia Medica Research
基金
四川省中医药管理局中医药科学技术研究资助专项项目(No.2003A05)
关键词
决明子
血脂
有效部位
Semen Cassiae
Blood Lipid
Effective Part