甲胎蛋白阴性肝癌66例临床病理分析

Clinicopathological Analysis of 66 Alpha-fetoprotein Negative Hepatocetlular Carcinoma Cases

分析66例甲胎蛋白(AFP)阴性肝癌的临床病理特征,并与220例AFP阳性肝癌相对照。结果发现AFP阴性肝癌患者性别、临床症状、肿块部位、有无包膜及细胞分化等与对照组差别不显著(P>0.05)。而50岁以上老年患者、Ⅱ期病人、单个及≤5cm肿块、术后1、3年生存率,血清乙肝病毒表面抗原(HBsAg)阳性和γ-谷氨酰转肽酶(γ-GT)升高等情况明显多于对照组(P<0.05或P<0.01)。提示,AFP阴性肝癌临床病理表现特异性不显著,诊断时需结合血清HBsAg、γ-GT等改变考虑。

The clinicopathological features of 66 alpha-fetoprotein(AFP)negative hepatocellular carcinoma (HCC)cases were analysed, and compared with 220 AFP positive HCC cases. The results showed that there were no significant difference between the two groups in patients' sex,symptoms and tumor' s sites, capsule and differentiation. The proportion of patients 50-year-old or more, term II, single tumor,≤ 5cm, 1 - 3 year survivals, serum hepatitis B virus surface antigen (HBsAg)and r-glutamine transpeptidase(γ-GT) abnormality all were higher in AFP negative HCC group than those in control group(P≤0. 05-0. 01). This suggested that the clinicopathological appearances of AFP negative HCC were not characteristic,and the changing of serum HBsAg and T-GT should be considered for a correct diagnosis.