梗阻性黄疸外周血和门静脉血甲状腺激素水平的临床研究

Clinical Study on Thyroid Hormones in Peripheral and Portal Vein Blood of Obstructive Jaundice

报道20例梗阻性黄疸(A组)和25例单纯胆囊结石(B组)患者外周血和门静脉血甲状腺激素水平。结果;1.在A组外周血和门静脉血中T_3、TSH显著低于B组(P<0.01),T_4无显著性差异(P>0.05)。2.在A组门静脉血T_M、T_G显著高于B组(P<0.01),外周血中无显著性差异(P>0.05)。3.在A组外周血中T_4显著高于门静脉血(P<0.01)。乙在B组外周血中TSH显著低于门静脉血(P<0.01)。5.相关分析显示TB、BTP与T_3呈现显著负相关(P<0.01)。结果表明梗阻性黄疸时不仅影响外周血和门静脉血甲状腺激素水平,而且影响甲状腺激素的反馈调节。

This article reported thyroid hormones in peripheral and portal vein blood in 20 patients with obstructive jaundice (group A) and 25 cases of simple gallbladder stones (group B). The findings showed that 3,5,3'-triiodothyroine (T3) and thyroid stimulating hormone (TSH) in peripheral and portal vein blood in group A were significantly lower than those in group B (P<0. 01) (3,5,3' ,5'-tetraiodothyronine (T4) was not obviously different between groups A and B (P>0. 05). Thyroid micromosal antibody (TM) and thyroglobulin (Tg) in portal vein blood in group A were significantly higher than those in group B (P<0. 01) ,TM and Tg were not obviously different between groups A and B in peripheral vein blood (P>0. 05)- T4 in peripheral vein blood was significantly higher than that in portal vein blood in group B. TSH in peripheral vein blood was obviously lower than that in portal vein blood in group B(P<0. 01). The regressive analysis indicated that serum total bilirubin (TB)and biliary tract pressure(BTP) were negatively related with T3(P<0. 01). The results indicated that obstructive jaundice not only affected thyroid hormones in peripheral and portal vein blood but also influenced feedback regulation of thyroid hormones.