慢性活动性肝炎患者血清透明质酸与e系统相关性研究

Study on Relationships between Serum Hyaiuronate and e System in Patients with Chronic Active Hepatitis

对72例HBsAg阳性经组织病理学确诊的各期慢性活动性肝炎进行血清透明质酸(HA)与e系统关系的研究,并结合临床及病理资料进行分析。结果表明:随着肝硬变的发生,血清HA值及抗-HBe阳性率显著增高(均P<0.05)。抗-HBe持续阳性组血清HA值最高,血清有HBeAg/抗-HBe转换组血清HA值最低。不伴肝硬变的患者,当发生抗-HBe转换时临床症状随之改善,ALT水平亦降低,血清HA值亦相应降低。而在肝硬变组,未发现HA随临床症状的改善而降低,ALT变化对HA影响甚微。不伴肝硬变患者,桥形坏死阳性组血清HA值及抗-HBe阳性率均高于桥形坏死阴性组。

The relationship between serum hyaluronic acid (HA) and e sytsem was studied in 72 patients with chronic active hepatitis defined by liver biopsies and HBsAg positive serum ,it was analysed together with clinical and histological data. The results showed that levels of HA and the positive rate of anti-HBe were significantly increased while hepatic cirrhosis occurred. The HA level was the highest in the anti-HBe continous positive group and it was the lowest in the HBeAg/anti-HBe serocon version group. The occurrence of anti-HBe serocon version was followed by the improvement of clinical symptoms and the decrease of ALT and HA levels in patients without cirrhosis but not in patients with cirrhosis. The HA levels and anti-HBe positive rate in the bridging necrosis positive group were higher than the bridging necrosis negative group.