肺心病急性加重期血管内皮细胞损伤与SOD间关系的观察

The Relationship between Endothelial Cell Injuries and SOD in Critical Stage of Acute Cor Pulmonale

观察33例肺心病急性加重期患者血浆内皮素(ET)、VW因子(VWF)、组织型纤溶酶原,激活物(t-PA)及其抑制物(PAI)和血清超氧化物歧化酶(SOD)变化。结果:肺心病急性加重期ET、VWF、PAI升高,SOD和t-PA活性下降,与对照组比较差异显著(均P<0.01)。SOD与PaO_2、pH、t-PA呈正相关(r分别为0.348、0.295、0.314,P<0.05),与PaCO_2、ET、VWF、PAI呈负相关(r分别为—0.312、—0.401、—0.421、—0.312,均P<0.05)。提示肺心病急性加重期低氧、CO_2潴留等因素可导致血管内皮损伤加重,两者互为因果,相互影响,在肺心病加重期的致病机理中有重要意义。

Plasma endothelin(ET),VWF,tissue-plasminogen activator(t-PA),PAI and SOD of 33 cases of acute cor pulmonale in critical stage were examined- The results showed that in patient group ET.VWF.PAI were higher,SOD,t-PA were lower than those of control group. There was a positive correlation between SOD and PaO2,pH,t-PA. There was a negative correlation between SOD and PaCO2,ET,VWK,PAI. The low level of antioxidant hypoxernia and CO2 retention may cause injuries of endothelial cells. These correlations may play an important role in the pathogenesis of this disease.