摘要
转化生长因子-β(transforminggrowthfactor-beta,TGF-β)具有多种生物学作用,翼状胬肉中也有其异常表达。TGF-β在翼状胬肉发病中的作用主要表现为:①能促进翼状胬肉上皮细胞,成纤维细胞的增殖和新生血管形成。②能促进多种细胞外基质(extracellularmatrix,ECM)的合成。③对翼状胬肉中的炎症和免疫反应也有介导作用。
Transforming growth factor-beta (TGF-β) has many biological functions and is one of the cytokines of abnormal expression in pterygium. The effect of TGF-β in the pathogenesis of pterygium mainly includes that TGF-β can enhance the hyperplasia of epithelial cell and fibroblast, increase the neovasularization growth, stimulate extracellular matrix (ECM) production and introduce the inflammation and immunoreaction.
出处
《国际眼科杂志》
CAS
2006年第3期661-663,共3页
International Eye Science