血清唾液酸测定在肺癌诊疗中的应用

Application of Serum Sialic Acid Test to the Diagnosis and Treatment of Lung Cancer

应用单一试剂化学比色法分别检测健康组、肺癌组、肺部炎症组和肺结核组患者血清唾液酸，并对４１例肺癌患者治疗前后血清唾液酸水平进行动态观察。结果：①肺癌组血清唾液酸明显升高，与健康组比较有极显著性差异（Ｐ＜０．０１）。与肺部炎症组及肺结核组比较也有显著性差异（Ｐ＜０．０５）。②肺部炎症组、肺结核组血清唾液酸均有升高，但不如肺癌组显著，与健康组比较Ｐ＜０．０５。③肺癌组中３０例患者经手术及化疗后病情缓解，血清唾液酸明显降低，与治疗前比较Ｐ＜０．０１，另１１例患者治疗后病情恶化，血清唾液酸明显升高，与治疗前比较Ｐ＜０．０１。此结果提示：血清唾液酸测定对肺癌诊断有一定意义。

Single reagent chromometric analysis for the measurement of serum sialic acid (SSA) levels has been used. This test has been applied to human sera of which came from normal in dividuals and patients with lung cancer, pneumonia and pulmonary tuberculosis.Track observing result of the level from 41 patients with lung cancer before and after treatment is especially interesting. It' s demonstrated that: ① SSA concentrations were found to be very significantly increased (p<0.01) in the group of lung cancer patients as compared to those of normal groups. There is a significant difference between SSA levels in the group with lung cancer and both those with pneumonia and pulmonary tuberculosis also (P<0. 05). ②SSA levels were found to be increased in both groups of pneumonia and pulmonary tuberculosis patients comparing with those of normal groups (P<0. 05) ,but it' s not so obviously as those with lung cancer. ③ With the remission by the surgery and chemotherapy,SSA levels were found to be reduced obviously(P<0.01) in 30 patients with lung cancer as compared to those before treatment. The other 11 patients were determination after treatment. Their SSA concentrations became higher obviously than those before treatment (P<0. 01). Here we show that determination of SSA has important value for diagnosis of lung cancer.