尿α-1微球蛋白和尿免疫球蛋白G与移植肾功能的关系

Relationship Between Urinary α-1 Mricroglobin,Urinary Immunoglobulin G and Allograft Function

目的研究肾移植术后受者尿α-1微球蛋白、尿免疫球蛋白G(IgG)的变化规律及其与移植肾功能短期转归之间的关系。方法29例肾移植受者,于肾移植术后第1、7、14、21、28天分别检测晨尿α-1微球蛋白和尿IgG含量;根据临床、实验室、影像学等检查综合评价移植肾功能状况;分析尿α-1微球蛋白和尿IgG与血清肌酐(SCr)的关系。结果在肾移植术后1月内,尿α-1微球蛋白、尿IgG与SC r水平相关。29例中移植肾功能恢复正常15例(A组),移植肾功能未恢复正常14例(B组);A组尿α-1微球蛋白显著降低(P<0.05),A组中符合尿α-1微球蛋白和尿IgG临界值(<10 mg/dL,<2 mg/dL)的受者检测例次明显多于B组(P<0.01)。两组间尿α-1微球蛋白/SC r比值存在显著差异。结论尿α-1微球蛋白和尿IgG与肾移植受者短期肾功能相关。

Objective To study the changes of the urinary α-1 microglobulin and urinary immunoglobulin G（IgG） and to investigate the relationship between these two proteins and the allograft function after renal transplantation.Methods Twenty-nine renal transplant recipients were included in the study. Urinary α-1 microglobulin and urinary IgG were analyzed at d 1, 7, 14, 21, 28 after renal transplantation. The allograft function was evaluated based on the clinical manifestations, laboratory and imaging examinations, and the relationship between urinary α-1 microglobulin, IgG and serum cretinine （SCr） were analysed. Results Urinary α-1 microglobulin and urinary IgG correlated with SCr after renal transplantation in one month. Of all the 29 cases, 14 experienced allograft function recovery （group A）, and 15 failed （group B）. Urinary α-1 microglobulin decreased significantly in group A（P 〈0.05）and the number of patients with urinary α-1 microglobulin and urinary IgG level below the borderline （ 〈 10 mg/dL and 〈2 mg/dL,respectively） was much bigger in group A than that in group B（P 〈0.01 ）. As to urinary α-1 microglobulin/SCr ratio, there was also a significant difference between the two groups. Conclusion Urinary α-1 microglobulin and urinary IgG correlates with the short-term renal function after renal transplantation.