盐酸米诺环素软膏治疗固定修复体引起的牙周炎的临床评价

The Clinical Evaluation on the Effects of Local Application of Minocycline Ointment in Treatment of Periodontitis Resulted from Fixed Partial Dentures

目的评价牙周袋内局部使用盐酸米诺环素软膏治疗人工冠和固定义齿引起的牙周炎的临床效果。方法选择由人工冠和固定义齿引起的牙周炎患者32例,随机分为实验组和对照组。在龈上洁治和龈下刮治术后,实验组牙周袋注入盐酸米诺环素软膏,对照组牙周袋内只用生理盐水冲洗,每周1次,共4次。分别记录治疗前和治疗后4周、8周时的牙周指数,包括菌斑指数(PLI)、探诊出血(BOP)、牙周袋探诊深度(PD)等指标,并进行统计学分析。结果治疗后第4周、第8周,2组各项指标的测定值与治疗前比较均有明显改善,且实验组各指标的改善程度均明显优于对照组,差异均有统计学意义(P<0.01)。结论牙周袋内局部使用盐酸米诺环素软膏治疗人工冠和固定义齿引起的牙周炎能够获得较好的临床效果。

Objective To evaluate the clinical effects of minocycline ointment （Perioline） supplementary treatment on periodontitis resulted from fixed partial dentures. Methods 32 patients with periodontitis resulted from fixed partial dentures were enrolled in the study. Following supragingival scaling and suhgingival scaling the patients were randomly divided into test group （80 sites） and control group （88 sits）. The periodontal pockets were administered with either minocycline ointment in test group or saline solution in control group at baseline, week 2, week 3, and week 4. Clinical stores of plaque index （PLI）, bleeding on probing （BOP）, and probing depth （PD） were analyzed at baseline, week 4 and week 8. Results Both therapies resulted in significant improvements compared with baseline in terms of PLI, BOP and PD scores. Statistically significant differences were noted between the two groups, which suggested that the test group was superior to the control group. Conclusion Local administration of minocycline ointment （Perioline） in the treatment of periodontitis resulted from fixed partial dentures is safe and results in significant clinical improvement after supragingival and suhgingival instrumentation.