醛固酮合成酶基因CYP11B2(-344T/C)多态性对北京汉族高血压患者RAAS系统的影响

The Influence of Gene Polymorphism of Aldosterone Synthase Gene CYP11B2 (-344T/C) on RAAS in Han Nationality Essential Hypertensive Patients in Beijing

目的探讨醛固酮合成酶基因CYP11B2(-344T/C)多态性对北京汉族高血压患者肾素血管紧张素醛固酮(RAAS)系统的影响。方法采用多聚酶链式反应结合限制性内切酶片段长度多态性分析方法,检测345例原发性高血压(EH)病人和156例健康人(NE)醛固酮合成酶基因CYP11B2(-344T/C)多态性。并对2组人群的血压及各项临床指标和RAAS指标进行测定。结果EH组CC+CT基因型频率显著高于NE组;EH组C等位基因频率显著高于NE组(P<0·01)。在EH组中CC+CT基因型的ALD及ALD/REN显著高于TT基因型(P<0·05);2组间REN及ATⅡ差异无统计学意义(P>0·05);CC+CT基因型的ALD/REN显著高于TT基因型(P<0·05)。结论北京汉族人群中醛固酮合成酶基因CYP11B2(-344T/C)多态性与原发性高血压明显相关,并且对高血压患者的RAAS系统有显著影响。

Objective To evaluate the influence of gene polymorphism of aldosterone synthase gene CYP11B2（-344T/C） on RAAS in Han Nationality essential hypertensive patients in Beijing. Methods Polymerase chain reaction was used to detect the polymorphism of aldosterone synthase gene CYP11B2（-344T/C） in 345 hypertensive patients （EH） and 156 normotensive controls （NE）. Clinic blood pressure, biochemical indexes, the indexes of renin angiotensin-aldosterone system were also detected. Results The frequencies of CC＋CT genotype of aldosterone synthase gene CYP11B2（-344T/C） polymorphism among EH was significantly higher than that among NE（P〈 0.05）, the C allele of CYP11B2 （-344T/C） polymorphism among EH was significantly higher than that among NE（P 〈 0. 01）. ALD and ALD/REN of CC＋CT genotype of CYP11B2 （-344T/C） polymorphism were significantly higher than TT genotype（P〈0.05）. There were no significant difference in REN and AT Ⅱ. Conclusion The CYP11B2 （-344T/C） polymorphism could significantly influence the RAAS in Han Nationality essential hypertensive patients in Beijing.