冷冻/冷冻干燥处理对犬下颌骨生物力学性能的影响

Effects of Freezing and Freeze-drying on the Biomechanical Properties of Canine's Mandible

目的:探讨深低温冷冻/冷冻干燥处理对下颌骨生物力学性能的影响。方法:将12具新鲜比格犬下颌骨随机分成2组,第1组分为新鲜组和冷冻组、第2组分为新鲜组和冷冻干燥组,分别进行抗压和抗弯曲实验。结果:抗弯曲实验中冷冻骨和冻干骨的最大载荷与新鲜骨没有显著差别,抗弯曲实验中冷冻骨和冻干骨的最大载荷显著低于新鲜骨,分别降低了24%和30%,刚度显著高于新鲜骨。结论:经过冷冻或者冷冻干燥处理的同种异体下颌骨保持着较好的抗压能力,尽管抗弯曲能力下降较多,仍可以在移植后提供足够的支持力。

Objective： To investigate the effects of freezing and freeze -drying on the biomechanical properties of canine＇s mandible. Methods： Twelve fresh mandibles of beagle dogs were randomly divided into two groups ： group 1 was randomly divided into control group and freezing group; group 2 was control group and freeze -drying group. Each group had six half mandible. All the test pieces of mandible underwent bending and compression test. Results： There were no significant differences among the fresh bone, freezing bone and freeze -drying bone in the compression test. The maximal bending rigidities of freezing group and freeze - drying group were greatly higher than that of the fresh group but the anti - bending ability decreased 24 percents and 30 percents, respectively. Conclusion： The freezing and freeze - drying canine mandibles had similar anti - compressing properties compared with fresh mandibles. Despite of the decrease of anti - bending abilities, they were strong enough to reconstruct the mandible.