武汉地区淋球菌对6种抗菌药物敏感性的监测

Surveillance on susceptibility of Neisseria gonorrhoeae to six antimicrobial agents in Wuhan

目的:了解武汉地区淋球菌对6种抗菌药物耐药的发生率及耐药特征,为临床用药提供依据。方法:临床分离70株淋球菌,采用琼脂稀释法对淋球菌进行青霉素、四环素、阿奇霉素、环丙沙星、头孢曲松、大观霉素的敏感性的测定。结果:耐青霉素、四环素、阿奇霉素、环丙沙星的菌株分别占60.00%(42)、71.42%(50)、37.14%(26)、54.28%(38),同时耐2种及以上抗菌药物的多重耐药率为80%(56)。未发现耐大观霉素、头孢曲松的菌株。结论:武汉地区淋球菌环丙沙星耐药率及多重耐药率均增长迅速,头孢曲松、大观霉素可以作为武汉地区治疗淋病的首选药物,其余4种不作为首选。

Objective： To evaluate the susceptibility of Neisseria gonorrhoeae to six antimicrobial agents in Wuhan. Methods： The clinical isolates from patients with gonorrhoeae were collected. Agrose- dilution- method was used to test minimal inhibitory concentration （MIC） of antimicrobial agents including penicillin, tetracychne, ciprofloxacin, azithromycin, ceftriaxone and spectinomycin. Results： The positivity rates of resistant isolates to penicillin, tetracychne, azithromycin, ciprofloxacin were 60.00% （42/70）, 71.42% （50/70）, 37.14% （26/70） and 54.28% （38/70） respectively, and no resistant isolates to ceftriaxone or spectinomycin were found. Positivity rates of across - and multiple - resistant isolates to penicillin, tetracychne, azithromycin and ciprofloxacin were 80% （56）. Conclusion： Positivity rate of across- resistance increases rapidly, and the resistance to ciprofloxacin also increases rapidly. Ceftriaxone and spectinomycin should be the first choice in the treatment of gonorrhes at present in Wuhan area.