血小板膜糖蛋白Ⅰbα基因VNTR多态性与脑梗死的相关性研究

Relationship between the VNTR polymorphism of platelet glycoproteinⅠbα gene and cerebral infarction

目的探讨中国哈尔滨地区汉族人群血小板GPⅠbα基因VNTR多态性与脑梗死的关系。方法选择哈尔滨地区汉族人群137例经脑CT或MRI检查及临床确诊的脑梗死患者作为脑梗死组,105例健康者作为对照组,应用PCR技术进行VNTR多态性检测。结果脑梗死组GPⅠbαVNTR基因型和对照组间无统计学差异(P=0.286)。B等位基因频率在患者组较对照组高,但无统计学意义(OR:3.16,P=0.063)。多因素逐步Logistic回归分析结果显示,各基因型和等位基因不是影响脑梗死的独立因素。结论哈尔滨地区汉族人群血小板GPⅠbα基因VNTR多态性可能与脑梗死无相关性。

Objective To study the relationship between the VNTR polymorphisms of the platelet membrane GPⅠbα in harbin Han nationality and cerebral infaretion（CI）.Methods 137 cases with cerebral infarction confinneb by CT or MRI and 105 health individual controls from Harbin Han nationality were selected. All sub- jects were genotyped for VNTR polymorphisms in the gene for GP Ⅰbα through polymerase chain reaction. Resuits No significant association was found between CI and GP Ⅰbα gene VNTR polymorphism, although there was a trend in the increased prevalence of the B allele in patients compared with that of controls. Condusion Our findings indicate that no association exists between the VNTR polymorphism of platelet GP Ⅰbα gene and CI in Han race of Chinese Harbin.