载脂蛋白J基因多态性与2型糖尿病相关性分析

The association between apolipoprotein J gene polymorphism and type 2 diabetes

用PCR变性梯度凝胶电泳法研究载脂蛋白J基因外显子2和5的多态性,发现31例2型糖尿病(T2DM)病人的外显子5的突变杂合子频度高于正常对照(n=30)(100%vs77%,P<0.05),外显子2的突变杂合子频度也高于正常对照(61%vs40%)。提示这种突变可能与T2DM有关。

The study of apolipoprotein J gene polymorphism by PCR-DGGE showed that 31 patients with T2DM had higher frequencies of mutation heterozygotes in exon 5 （100% vs 76.7%） and in exon 2 （61.2% vs 40.0%）, as compared with normal control （n=30）. This snggests that apolipoprotein J exon 2 and 5 polymorphism may be associated with T2DM.