摘要
目的:探讨黄芪桂枝五物汤和方中不同药对对佐剂性关节炎大鼠的影响。方法:将黄芪桂枝五物汤按药对研究法拆方分组,观察全方及方中不同药对对佐剂性关节炎大鼠原发性、继发性关节炎的预防治疗作用,以及对红细胞超氧化物歧化酶(SOD)、全血谷胱甘肽过氧化物酶(GSH-PX)活性、血浆丙二醛(MDA)、血清一氧化氮(NO)含量的影响。结果:全方及方中各药对均能显著抑制关节炎大鼠的原发性关节炎、继发性关节炎,使佐剂性关节炎(AA)大鼠过高的MDA、NO降低,使已降低的SOD、GSH-PX升高。结论:黄芪桂枝五物汤对大鼠佐剂性关节炎有治疗作用,此作用可能与其降低制脂质过氧化,恢复抗氧化酶活性,抑制致炎因子NO的合成等有关;全方疗效明显优于任何一组药对配伍,方中其他药均能增强黄芪的作用。
Objective: To observe the effects of Huangqi Guizhi Wuwu Tang (HQGZWWT) on rats with adjuvant arthritis(AA). Methods: The therapeutic effect on AA rats, including the influence on primary and secondary arthritis, the influence on superoxide dismutase(SOD) activity of red blood cells, glutathion peroxidase (GSHPX) activity in blood, and on contents of malonic aldehyde (MDA), nitrous oxide (NO) of HQGZWWT were observed. Results: HQGZWWT could not only markedly defend and treat the primary and secondary arthritis of AA rats, but also decrease the contents of MDA and NO in the AA ratsblood serum, boost up activity of SOD and GSH-Px. Conclusion: HQGZWWT has signigicant therapeutic effects on AA rats, which might be related to both of decreasing lipid peroxidation and inhibiting synthesis of NO.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第3期3-5,共3页
Pharmacology and Clinics of Chinese Materia Medica
基金
广州中医药大学总体规划课题(编号:KOC01012)
关键词
黄芪桂枝五物汤
配伍
佐剂性关节炎
Huangqi Guizhi Wuwu decoction (黄芪桂枝五物汤)
adjuvant arthritis