摘要
目的:观察商陆对大鼠阿霉素肾病模型的治疗作用及可溶性白介素2受体(sIL-2R)水平变化。方法:大鼠尾静脉分次注射阿霉素共7.5mg/kg制备肾病模型,分别灌以商陆4g/kg、1g/kg或强的松16mg/kg,连续2周,观察动物血清白蛋白、尿蛋白及sIL-2R的改变。结果:商陆对阿霉素肾病模型大鼠具有减少尿蛋白、提高血清白蛋白的作用,sIL-2R水平各治疗组均下降,其中高剂量商陆组与模型组差异明显。结论:商陆对阿霉素肾病具有治疗作用、其作用可能与下调sIL-2R水平有关。
Objective： To investigate the effect of crude extract from phytolaccae on adriamicin - induced nephropathy rats and sIL- 2R change of the rats. Methods： Male SD rat nephropathy was induced by multiple injection of adriamicin to vena caudalis, with total dose 7.5mg/kg. Then the model rats were fed with crude extract from phytolaccae （4g/kg. d or 1g/kg. d） or prednisone （16mg/kg. d） for 2 weeks. Serum albumin, urine protein and blood fat were measured. Results： Crude extract from phytolaccae can decrease urine protein, elevate serum albumin（compared with model group P 〈 0.05）. There is no statistic difference between the effects of the extract and prednisone （P 〉 0.05）. sIL-2R decreased in all treated groups, with a significant decrease in high dosage group （P 〈 0.05 compared with model group）. Conclusion： Phytolaccae has therapeutical effect to nephrotic rats, which may be related to the reduction of sIL - 2R.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第3期107-108,共2页
Pharmacology and Clinics of Chinese Materia Medica
