肝脂康颗粒剂抗脂肪肝作用机理的研究

A study on anti-fatty liver effect of Ganzhikang granules

目的:探讨肝脂康颗粒治疗脂肪肝的作用机理。方法:采用小鼠d l-E(d l-乙硫氨酸)或高脂-白酒饮食两种脂肪肝模型,观察肝脂康颗粒对脂肪肝肝匀浆SUP(上清液)中LPO(过氧化脂质),肝脂、血脂,及肝功能等指标的影响。结果:肝脂康颗粒对d l-E模型脂肪肝小鼠的肝脂、血脂,肝功能无明显影响,但对其脂肪变性肝损伤有明显保护作用;还能使高脂-白酒饮食模型脂肪肝小鼠的肝脂、血脂,肝匀浆SUP中LPO及肝功值降低。结论:肝脂康颗粒对d l-E诱导型小鼠脂肪肝作用微弱,对高脂-白酒饮食型小鼠脂肪肝具有良好的降脂和保肝作用。

AIM： To investigate the effect of Ganzhikang granules on protecting the liver against fatty accumulation. Methods： A couple of fatty liver animal models were established with dl-ethionine or high lipid-alcohol food in mice respectively. To observe the effect of Ganzhikang granules on the content of liver-lipid, blood-lipid, ALT, AST of liver, and LPO of liver cells. Results： Lack of effect of Ganzhikang granules on the content of liver-lipid, blood-lipid, ALT, AST of liver（P 〉 0.05）. however, it can distinctly protect the damage of liver cells as a result of fatty accumulation（P 〈 0.05）, which the modle was induced by dl-ethionine; All of the content of liver-lipid, blood-lipid, LPO of liver cells, and ALT, AST of liver can be reduced remarkly by Ganzhikang granules （P 〈 0.05） , which the model was induced by high lipid-alcohol food. Conclusion： The effect of Ganzhikang granules on fatty liver is faint that the modle was reduced by dl-ethionine. To the modle that was induced by high lipid-alcohol food, Ganzhikang granules had significant effects on reducing the lipid of body and protecting the function of liver.