HIF-1α在胃癌组织中的表达及其临床意义

The expression of HIF-1 α in the tissues of gastric cancer and their clinical value

目的:研究低氧诱导因子-1α(Hypoxia-induciblefactor-lα,HIF-lα)在胃癌组织中的表达及临床意义。方法:收集60例胃癌标本(胃癌组)为研究对象,另设20例胃溃疡(胃溃疡组)和20例正常胃黏膜组织(正常组)标本作对照。采用免疫组织化学染色S-P法检测60例胃癌、20例胃溃疡及20例正常胃黏膜组织标本中HIF-1α蛋白的表达情况。结果:胃癌组中HIF-1α的阳性表达率为66.7%(40/60),而胃溃疡组和正常组不表达,差异有显著性(P<0.01)。Ⅰ+Ⅱ期胃癌的表达率为45.0%(9/20),Ⅲ+Ⅳ期的表达率为77.5%(31/40),二者差异有显著性(P<0.05)。HIF-1α与胃癌的浸润深度、淋巴结转移、远处转移存在正相关,而与肿瘤的病理类型分化程度、大小无显著相关性。结论:胃癌组织中HIF-lα呈高表达,且表达率与临床病理分期相关。

Objective： To study the expression of HIF-1α （Hypoxia-inducible factor-1α） in the tissues of gastric cancer and it＇s clinical value. Methods：Cases patients with gastric cancer. 20 cases were collected with gastric ulcer and 20 normal tissues were selected as control group. The expression of HIF-1α in the tissues of the gastric cancer, the gastric ulcer and the normal control group were examined with the SP method of the immunological histochemistry. Results： The positive HIF-1α expression rate in the tissues of the gastric cancer was 66.7% （40/60）, while there were no expressions in the other two groups. There were statistically significance in these groups（P〈0.01）. The expression rate of the HIF-1α in the gastric cancer with Stage Ⅰ ＋ Ⅱwere 45.0%, and in Stage Ⅲ＋Ⅳ were 77.5%. There were statistically significance （P〈0.05） .The HIF-1α were significantly correlated with the infiltration depth, the lymph node metastasis and remote metastasis, and there were no correlation with the pathology and the lesion size of the tumor. Conclusion： The HIF-1α is found to be highly expressed in the tissues of the gastric cancer, and the expression of the HIF- 1α correlated with the clinical pathological staging.