摘要
瞄准:在 immunoproliferative 的诊断和预知评估 syndecan-1, bcl6 和 p53 的角色小肠的疾病(IPSID ) 并且学习 kappa (kappa ) 和人字缝尖(人字缝尖) 的侧面轻链和 IgA 重链。方法:学习由 IPSID 的 11 个盒子和包括了 11 正常肠粘膜和回肠的 11 高等级 B 房间淋巴瘤的控制的类似的数字组成了。分析的参数包括了临床的侧面,生物化学并且另外的实验室调查,放射线学并且组织检查所见包括免疫组织化学。结果:所有 IPSID 箱子有可论证的浆液 IgA 重链和重粘膜血浆房间渗入。根据 Galian 的组织学的阶段,有有舞台 A 的 4 个病人并且 7 与舞台 B。kappa 和人字缝尖轻链在 7 个病人是过去表示的;1 舞台 A H pylori 的耐心的有的 H pylori 积极的活跃胃炎和根除导致了疾病宽恕。舞台 A 活体检视为 syndecan-1 有更高的表示,当舞台 B 为 bcl6 和 p53 有更高的表示时。Syndecan-1, kappa 和人字缝尖轻链和 IgA 重链与 bcl6 和 p53 显示出反的关系。所有病人与 doxycycline 被对待。砍政体在得了坦率的淋巴瘤的 5 个病人被增加。三由于广泛的机关渗入死于疾病。结论:象 syndecan-1, kappa 和人字缝尖轻链和 IgA 重链一样的某些免疫标记能具有在识别早阶段 IPSID 的许多帮助。舞台 B IPSID 比上演 IPSID 为 bcl6 和 p53 显示出更高的表示。bcl6 和 p53 表情与一个更多的病沉重期舞台和好攻击的瘤行为相关。
AIM: To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease (IPSID) and to study profiles of kappa (κ) and lambda (λ) light chains and IgA heavy chain.
METHODS: The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry.
RESULTS: All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian's histological staging, there were 4 patients with stage A and 7 with stage B. κ and ;λ light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1,κ and λ light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration.
CONCLUSION: Certain immunomarkers like syndecan-1,κ and λ light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.
关键词
小肠疾病
病理机制
诊断
预防
BCL6
P53
IPSID
Syndecan-1
bcl6
p53 protein
κ and λ light chains
Alpha heavy chain
H pylori