Roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease

瞄准：在 immunoproliferative 的诊断和预知评估 syndecan-1， bcl6 和 p53 的角色小肠的疾病(IPSID ) 并且学习 kappa (kappa ) 和人字缝尖(人字缝尖) 的侧面轻链和 IgA 重链。方法：学习由 IPSID 的 11 个盒子和包括了 11 正常肠粘膜和回肠的 11 高等级 B 房间淋巴瘤的控制的类似的数字组成了。分析的参数包括了临床的侧面，生物化学并且另外的实验室调查，放射线学并且组织检查所见包括免疫组织化学。结果：所有 IPSID 箱子有可论证的浆液 IgA 重链和重粘膜血浆房间渗入。根据 Galian 的组织学的阶段，有有舞台 A 的 4 个病人并且 7 与舞台 B。kappa 和人字缝尖轻链在 7 个病人是过去表示的；1 舞台 A H pylori 的耐心的有的 H pylori 积极的活跃胃炎和根除导致了疾病宽恕。舞台 A 活体检视为 syndecan-1 有更高的表示，当舞台 B 为 bcl6 和 p53 有更高的表示时。Syndecan-1， kappa 和人字缝尖轻链和 IgA 重链与 bcl6 和 p53 显示出反的关系。所有病人与 doxycycline 被对待。砍政体在得了坦率的淋巴瘤的 5 个病人被增加。三由于广泛的机关渗入死于疾病。结论：象 syndecan-1， kappa 和人字缝尖轻链和 IgA 重链一样的某些免疫标记能具有在识别早阶段 IPSID 的许多帮助。舞台 B IPSID 比上演 IPSID 为 bcl6 和 p53 显示出更高的表示。bcl6 和 p53 表情与一个更多的病沉重期舞台和好攻击的瘤行为相关。

AIM： To evaluate roles of syndecan-1, bcl6 and p53 in diagnosis and prognostication of immunoproliferative small intestinal disease （IPSID） and to study profiles of kappa （κ） and lambda （λ） light chains and IgA heavy chain. METHODS： The study consisted of 11 cases of IPSID and similar number of controls which included 11 of normal intestinal mucosa and 11 of high grade B cell lymphoma of ileum. The parameters analyzed included clinical profiles, biochemical and other laboratory investigations, radiologic and histological findings including immunohistochemistry. RESULTS： All IPSID cases had demonstrable serum IgA heavy chain and heavy mucosal plasma cell infiltration. According to Galian＇s histological staging, there were 4 patients with stage A and 7 with stage B. κ and ;λ light chains were over-expressed in 7 patients; 1 stage A patient had H pylori-positive active gastritis and eradication of H pylori led to disease remission. Stage A biopsies had higher expression for syndecan-1, while stage B had higher expression for bcl6 and p53. Syndecan-1,κ and λ light chains and IgA heavy chain showed inverse relationship with bcl6 and p53. All patients were treated with doxycycline. CHOP regime was added in 5 patients who developed frank lymphoma. Three died of the disease due to extensive organ infiltration. CONCLUSION： Certain immunomarkers like syndecan-1,κ and λ light chains and IgA heavy chain could be of much help in identifying early stage IPSID. Stage B IPSID showed higher expression for bcl6 and p53 than stage A IPSID. bcl6 and p53 expressions correlated with a more advanced disease stage and aggressive tumour behavior.