女性吸毒者戊型肝炎病毒感染状况及其影响因素的研究

The Study of HEV Infection and Its Risk Factors in Female Drug Abusers

目的探讨女性吸毒者戊型肝炎病毒感染状况及其影响的因素。方法304名女性吸毒人员为调查对象,对其社会学特征、饮食习惯、吸毒行为特点等方面进行面对面的问卷调查,并抽取血标本。用ELISA法测定其血清中戊型肝炎病毒的IgG抗体(抗-HEVIgG)的含量。结果304名女性吸毒人员HEV总感染率为6.25%,不同婚姻状况及不同饮用水源戊型肝炎感染率无显著性差异。饮酒者戊型肝炎病毒感染率(11.76%)显著高于不饮酒者(4.11%)(P<0.05)。静脉注射吸毒者戊型肝炎病毒感染率(12.09%)显著高于非静脉注射吸毒者(3.76%)(P<0.01)。与他人共用注射器者戊型肝炎感染率(10.31%)显著高于未与他人共用注射器者(4.35%)(P<0.05)。结论吸毒人群中戊型肝炎病毒感染的高危因素是饮酒、静脉注射吸毒、共用注射器和/或针头、注射器和/或针头消毒情况。

Objective To estimate the risk factors and the infection rate of HEV among female drug abusers. Methods 304 female drug abusers were selected by cross-sectional survey from Zhuzhou Narcotic Abstention institute. Self-designed questionnaire was used to investigate all subjects＇ demographic characteristic, eating habit, drug using behavior. The anti-HEV IgG was tested by ELISA. Results The overall infection rate of HEV was 6.25%. There was no association between the HEV infection rate and marriage status and different water sources which were used by the subjects. The HEV infection rate of the drinkers among the subjects （11.76%） was statistical significant higher than that of the non-drinking ones （4.11%） （P 〈 0.05）. HEV infection rate of intravenous drug users （12.09%） was statistical significant higher than that of the non-intravenous ones （3.76%） （P 〈 0.01）. HEV infection rate of the ones using the same syringes with others （10.31%） was significantly higher than that ofthe ones who didn＇t use the same syringes with others （4.35%） （P 〈 0.01）. Conclusion The risk factors ofHEV infection were drinking, intravenous drug using, using the same syringes with others and syringes sterilizing.