dl-邻氯苯基甘氨酸的合成研究

Study on Synthesis of dl-Ortho-Chlorophenylglycine

目的合成二磷酸腺苷(ADP)受体拮抗剂氯吡格雷的原料dl-邻氯苯基甘氨酸。方法采用邻氯苯甲醛为原料,经两条路线分别合成目标化合物。结果通过氰基化、水解和中和三步反应制得目标化合物,收率分别为43.5%和50%。经IR和1H-NMR表征结构。讨论通过改进合成方法,产品收率高于文献报道。

Objective Aim To synthesis ortho-chlorophenylglycine as a reaction agent for prepartion of ADP receptor antagonist Clopidogrel. Method Starting from ortho-chlorobenzaldehyde, the target molecular was obtained by means of two different synthetic routes. Result The title compound was prepared with three steps including cyanation, and total yield 43.5% and 50% respectively, and its chemical structure was characterized by IR and ^1 H-NMR spectra. Conclusion through the modifed method, the product yields are higher than that reported in the literature.