纳洛酮早期应用对急性中重型颅脑损伤神经功能恢复的探讨

To study on naloxone in the early treatment for the neural function'recovery of acute moderate and severe brain injuries.

目的探讨早期应用纳洛酮对急性中重型颅脑损伤神经功能的疗效。方法对所收治44例急性颅脑损伤患者随机分为纳洛酮组和常规对照组各22例,对两组患者同期的格拉斯哥昏迷评分(GCS)、格拉斯哥预后评分(GOS)及运动语言功能、综合生活质量计分进行对比分析。结果纳洛酮组患者的GCS评分及GOS评分在治疗和随访期间均较对照组提高,伤后2月神经功能恢复良好率高于对照组。结论在及时手术及常规治疗的前提下应尽早使用纳洛酮促进急性中重型颅脑损伤患者神经功能恢复。

Objective To study the effect of naloxone＇s early teartrnent for neural function of acute moderate and severe brain injuries. Methods 44 patients with acute brain injuries were randomly assigned to 2 groups （22 cases were treated with naloxone and 22 cases were control）. The Glasgow Come Scale（GCS）, the Glasgow Outcome Scale（GOS）, the functional score of language and movement in both groups were compared. Results The scores of GCS and COS in the naloxone group were significantly higher than those in the control group respectively. After 2 months, the neural function recovery of patients received naloxone is better than that of control group. Conclusion Large dosage of naloxone in early treatment with surgical treatrment and regular treatment is important to promote the recovery of neural ftmction for acute moderate and severe brain injuries.