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肿瘤活化前药的研究与应用进展 被引量:1

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作者 李铭东 吉民
出处 《药品评价》 CAS 2006年第3期206-213,共8页 Drug Evaluation
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同被引文献44

  • 1易静,郝晓柯,苏明权.肿瘤的酶-前药疗法[J].国外医学(肿瘤学分册),2005,32(6):413-416. 被引量:1
  • 2何亮.前药的研究进展[J].世界临床药物,2006,27(1):55-58. 被引量:8
  • 3Stella VJ, Himmelstein KJ. Prodrugs and site-spe- cific drug delivery[J].J Med Chem, 1980, 23(12) : 1275-1282.
  • 4Testa B. Prodrugs: bridging pharmacodynamic/ pharmacokinetic gaps [J]. Curr Opin Chem Biol, 2009, 13(3): 338-344.
  • 5Ettmayer P, Amidon GL, Clement B, et al. Les- sons learned from marketed and investigational pro- drugs [J]. J Med Chem, 2004, 47(10): 2393- 2404.
  • 6Beaumont K, Webster R, Gardner I, et al. Design of ester prodrugs to enhance oral absorption ofpoorly permeable compounds: challenges to the dis- covery scientists[J]. Curr Drug Metab, 2003, 4 (6) : 461-485.
  • 7Wu KM. A new classification of prodrugs: regula- tory perspectives[J]. Pharmaceuticals, 2009, 2 (3):77-81.
  • 8Rautio J, Kumpulainen H, Heimbach T, et al. Prodrugs: design and clinical applications[J].Nat Rev Drug Discov, 2008, 7(3) : 255-270.
  • 9Testa B. Prodrug research: futile or fertile[J]. Bio- chem Pharmacol, 2004, 68(11): 2097-2106.
  • 10Cundy KC, Sastry S, Luo W, et al. Clinical phar- macokinetics of XP13512, a novel transported pro- drug of Gabapentin [J]. J Clin Pharmacol, 2008, 48(12) : 1378-1388.

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