摘要
作者用高效液相色谱法（ＨＰＬＣ）对苦参碱的大鼠药物动力学进行研究。其药时曲线符合２室开放模型，Ｋａ为３．４００／ｈ，Ｋｅ为０．５２３／ｈ，Ｔ１／２为３．９７１ｈ。组织分布以肾脏最高，依次为脾、肺、脑、心、血；脏器药物浓度约在０．５ｈ达峰值（肺在１ｈ达峰值），与血药浓度一致，给药后４８ｈ仍可测得。药物主要经肾脏排泄。苦参碱的吸收完全而迅速，长期给药不存在积蓄。
The paper reports the pharmacokinetics of matrine in rats after oral administration. The concentrations in biological samples were detected by HPLC. The study shows that concentrations-time curve of matrine in blood conformed to a open 2-compartment model after 50mg/kg intragastric. Matrine obsorntion was rapid and complete,The peak of plasma and tissue level appeared in 0.5h. The distribution of matrine in rat’s tissues were as follows:highest in kidney, next in liver,spleen,lung,heart,brain,blood respectively,and were still can be detected after 48 hours.Urine was the main route of excretion. There was no accumulation in rats after 50mg/kg·intragastric qd-1×21d.
出处
《上海第二医科大学学报》
CSCD
1996年第4期250-253,共4页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
苦参碱
药物动力学
matrine
pharmacokinetics
accumulation
