肿瘤坏死因子-α基因-308多态性与同种异体肝脏移植急性排斥反应的Meta分析

A Meta-analysis of TNF-αgene-308 Polymorphism in the Risks of Renal Allograft Hepatic Rejection

目的运用Meta分析的方法综合评价肿瘤坏死因子-α基因-308位点基因多态性与同种异体肝脏移植急性排斥反应发生风险的关系。方法检索MEDLINE、EMBASE和中国生物医学文献数据库(中文),纳入符合质量评价要求、涉及肿瘤坏死因子-α基因-308位点基因多态性与同种异体肝脏移植急性排斥反应关联的队列研究和病例对照研究。应用RevMan4.2软件进行统计分析。结果8个关于西方人群的研究结果表明:肿瘤坏死因子-α基因-308位点高分泌基因型患者肝脏移植后急性排斥发生率与低分泌基因型患者间差异无统计学意义(OR=1.35,95%CI=0.78～2.35,P=0.28)。结论西方人群肿瘤坏死因子-α基因-308位点高分泌基因型与急性排斥反应间未见明显相关关系,但需增加样本量,提高研究质量进一步研究。

Objective To investigate the association between TNF-α gene-308 polymorphism and hepatic allograft acute rejection using the methods of rneta-analysis. Methods References,involving the association between TNF-α gene-308 polyrnorphisrn and hepatic allograft acute rejection, were retrieved through the computerized MEDLINE, EMBASE, Cochrane and CBM and also meet the needs of quality appraisal. All of the data were analysed using RevMan4.2 software. Results There was no significant difference between the TNF-α gene frequencies of A/A or A/G and the odds of renal allograft acute rejection（OR=1.35, 95%CI=0.78-2.35,P=0.28）. Conclusion The rneta-analysis suggests the TNF-α gene-308 polyrnorphisrn might have no relation to hepatic allograft acute rejection, but we must further identify it by big sample size and high quality studies.