胃泌素及胃泌素释放肽在胃癌组织中的表达及意义

The expressions of gastrin and gastrin releasing peptide in gastric cancer

目的 研究胃癌组织中胃泌素（Gastyin，GAS）、胃泌素释放肽（Gastrin releasing peptide，GRP）的表达及其意义。方法采用组织芯片技术制作60例胃癌组织芯片，同时用S—P免疫组织化学方法检测胃癌组织芯片中GAS、GRP的表达。结果 60例胃癌中GAS阳性率为31．7％；GRP阳性率为11．7%。中、低分化胃癌GAS、GRP的表达阳性率高于高分化胃癌（P〈0．05），黏液腺癌、印戒细胞癌GAS、GRP的表达阳性率显著高于其它组织学类型胃癌（P〈0．01），胃癌GAS、GRP阳性表达与淋巴结转移相关（P〈0.05）。结论 本研究结果提示中、低分化胃癌，黏液腺癌、印戒细胞癌可作为胃癌内分泌治疗的主要适应证。

AIM To study the expressions of gastrin （GAS）and gastrin releasing peptide （GRP） in gastric cancer, METHODS Tissue chip was made of tissue blocks from 60 cases of gastric cancer and SP immunohistochemical method was employed to detect the expressions of GAS and GRP, RESULTS GAS and GRP expressions were positive in 31. 7% and 11.7% of the 60 gastric cancer patients,with higher positive rates in moderately and poorly than inwell differentiated cancers（ P d0,05）, in mucinous adenocarcinomas and signet - ring Cell carcinomas than in papillary and tubular adenocarcinomas （ P 〈 0.01）. CONCLUSIONS Moderately and poorly differentiated gastric carcinomas, such as mucinous adenocarcinomas and signet - ring cell carcinomas, are more likely to express GAS and GRP, and are more likely to be the candidates for endocrine therapy.