赛乐特治疗功能性消化不良30例临床观察

Application of seroxat in the treatment of functional dyspepsia

目的 探讨抗抑郁药物赛乐特治疗功能性消化不良（FD）的临床效果。方法 将60例功能性消化不良病人随机分成两组，抗抑郁组给予赛乐特20mg／d；常规组根据个体化治疗原则，应用消化系统药物。两组均配合支持性心理治疗。治疗时间均为8周。入组者治疗前、后进行焦虑自评量表（SaS）和抑郁自评量表（SDS）测评及FD症状评分。结果 FD病人的SAS和SDS评分与常规组之间存在显著差异（P〈0．01）；治疗8周后抗抑郁组SAS和SDS评分显著低于常规组（P〈0．01），FD评分也明显低于常规组（P〈0．05）。结论 FD病人普遍存在情绪问题，抗抑郁药物适合治疗有抑郁情绪的FD病人，不仅改善情绪状态而且明显改善FD症状，疗效显著。

AIM To evaluate the therapeutic efficacy of the antidepressant seroxat in the treatment of functional dyspepsia （FD）. METHODS Sixty patients with FD were divided randomly and equally into two groups receiving either seroxat or conventional remedy for 8 weeks. Both groups also got supportive psychotherapy concurrently. Self- rating anxiety scale （SAS）, self- rating depression scale （SDS）and symptomatic assessment were done before and after the treatment. RF_.SI^TS Scores for SAS, SDS and symp- toms were not different between the two groups before the treatment,but significantly lower in seroxat - treated group than the other group after the treatment （ P 〈0.0.5）. CONCLUSIONS FD patients usually have psychological problems, and antidepressants are recommended.