功能性消化不良心理调查与诊治

Psychological Investigation and Treatment of Functional Dyspepsia

目的探讨功能性消化不良(FD)与精神心理因素的关系及胃肠动力药与抗焦虑,抗抑郁药物对其疗效的影响。方法对220例FD患者采用焦虑自评量表(SAS)、抑郁自评量表(SDS)评分,并将心理测评异常的132例患者随机分成莫沙必利组、赛乐特组和综合组三组。8周为1疗程。莫沙必利组给予莫沙必利5mg、tid、po;赛乐特组给予赛乐特10mg,qm、po;综合组给予莫沙必利5mg,tid加赛乐特10mg、qm、po;治疗前后分别对其进行FD症状、SAS、SDS评分。结果FD患者各量表均分显著高于常模(P<0.01)。赛乐特治疗FD有效率36.37%,莫沙必利治疗FD有效率65.91%,两者合用疗效最佳,有效率为84.09%,三组间有显著差异。结论FD与精神心理因素关系密切,胃肠动力药联合抗焦虑、抗抑郁药治疗能明显提高FD患者的疗效。

Objective To explore relationship between functional dyspepsia （FD） and psychological factors, and study the efficacy of prokineties and antianxiety drugs, antidepressants. Methods Totally 220 FD patients were assessed with SAS, SDS, then compared the scales with norm, and 132 FD patients with abnormal SAS or/and SDS scores were randomly divided into mosapfide, paroxetine, and mosapride plus paroxetine groups, each group have 44 cases and were treated for 8 weeks.Mosapride group were given mosapride 5mg, tid, pe; Paroxetine were given 10mg, qm, po.Mosapride plus paroxetine group were given mosapride 5mg, tid, pe plus paroxetinelOmg, qm, po. Results The average scores of every scale were significantly higher than that of norms （ P 〈 0.01） .The total effective rate of mosapride, paroxetine, mosapricl plus groups was 36.37%, 65.91%, and 84.09%, respectively, There were significant differences among 3 groups. Conclusions FD has close relationship with psychological factors, combination of prokcinetics and antianxiety drugs, antidepressants can realize good results in the treatment of FD patients.