厄贝沙坦预防阵发性房颤复发的疗效观察

The effect of single irbesartan or combined with amiodarone on prevention of recurrence paroxysmal atrial fibrillation

目的评价厄贝沙坦或联合小剂量胺碘酮在预防阵发性房颤复发中的疗效。方法阵发性、症状性房颤患者88例,随机分为厄贝沙坦+胺碘酮、胺碘酮、厄贝沙坦和空白对照组,分别给予厄贝沙坦150mg/d+胺碘酮0.2mg/d、胺碘酮0.2mg/d、厄贝沙坦150mg/d,随访1年。观察房颤复发率、第一次复发间隔、发作频率、房颤持续时间等。结果①房颤复发率:厄贝沙坦+胺碘酮组显著低于对照组组(52.2%,85.0%,p<0.01);②第一次复发间隔:厄贝沙坦+胺碘酮组显著高于厄贝沙坦和对照组(p<0.01;p<0.01),与胺碘酮组比较差异不显著(p>0.05),胺碘酮组又高于对照组(p<0.05),厄贝沙坦组与对照组无显著性差异(p>0.05);③发作频率:厄贝沙坦+胺碘酮组显著低于厄贝沙坦组(p<0.01)、对照组(p<0.01)以及胺碘酮组(p<0.05),胺碘酮组也显著低于厄贝沙坦组(p<0.05)、对照组(p<0.05);厄贝沙坦组与对照组间无显著性差异(p>0.05);④房颤持续时间:厄贝沙坦+胺碘酮组低于对照组(p<0.01)、厄贝沙坦组(p<0.01)和胺碘酮组(p<0.05),胺碘酮组也低于对照组(p<0.05)。厄贝沙坦组与对照组、胺碘酮组比较,均无显著性差异(p>0.05;p>0.05)。结论单用厄贝沙坦与小剂量胺碘酮联合应用,预防房颤复发优于单用胺碘酮。

Objective to estimate the effect of single using irbesartan or irbesartan add to amiodarone on recurrence of paroxysmal atrial fibrillation （PAF）. Method 88 patients with PAF were divided randomly into four group, irbesartan combined with amiodarone （IRB＋AMD） group, amiodarone （AMD） grouP, irbesartan （IRB） group and control （CONT） group, accepting irbesartan 150mg add to amiodarone 200mg daily, amiodarone 200mg daily, irbesartan 150 mg daily or nothing respectively. The follow-up lasted one year. The AF recurrence mortality, AF recurrence interval, AF recurrence frequency and AF duration （AF-DUR） were observed during one year. Results ①In IRB＋AMD group, AF-RM was lower than that in CONT group; ②AF-RI： AF-RI in IRB＋ AMD group was higher than that in IRB and CONT group, but not higher significantly than that in AMD group; AF-RI in AMD group was also higher than that in CONT group. ③ AF-RF： In IRB＋AMD group, AF-RF was lower markedly than that in IRB, CONT and AMD group. AF-RF in AMD group was aslo lower than that in IRB and CONT group. Otherwise, AF-RF in IRB was as same as that in CONT group. ④AF-DUR：AF-DUR in IRB ＋AMD group was lower that in CONT, IRB and AMD group. AF-DUR in AMD was also lower than that in CONT group. Conclusion Irbesartan 150mg daily combined with amiodarone 200mg daily, it＇s effects in prevention of AF recurrence is better than amiodarone alone.