黄芪育阴煎干预2型糖尿病患者胰岛素抵抗及相关因素的临床研究

Clinical Study on Huangqi yuyin recipe Interfering in Insulin Resistance and Related Factor of Type 2 Diabetes

目的观察黄芪育阴煎治疗2型糖尿病及胰岛素抵抗(IR)相关指标的临床疗效。方法治疗组33例采用自拟方黄芪育阴煎治疗,观察治疗前后空腹血糖(FBG)及餐后2h血糖(PBG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、c-肽、血脂,并计算胰岛素敏感指数(ISI)评估IR。结果治疗组治疗后FBG,PBG及HbA1c较治疗前显著降低(P<0.05),总有效率100%,显效率83.4%;血浆总胆固醇(TC),低密度脂蛋白胆固醇(LDL-C)明显降低(P<0.05),高密度脂蛋白胆固醇(HDL-C)明显升高(P<0.05),胰岛素、c-肽及ISI均有明显下降(P<0.05)。结论黄芪育阴煎具有明显的降糖作用,能显著增加胰岛素敏感性,从而改善胰岛素抵抗,且对血脂紊乱及临床症状有明显改善。

Objective To investigate the related index and clinical effect of huangqi yuyin recipe treating type 2 diabetes and insulin resistance（ IR）. Methods The treatrnent group which was made up of 33 patients were treated with huangqi yuyin recipe examine fasting blood glucose（FBG）, 2-hour-postprandial blood glucose（PBG）, glycated hemoglobin（ HbA1c）, fasting insulin（ FINS）, C peptide and blood fat before anti after treatment, calculating insulin susceptible index（ISI） to evaluate IR. Results After treatment, FBG, PBG and HbA1c fell clearly in the treatment group （ P 〈 0. 05）, the total effective rate was 100%, the display rate was 83.4% ;plasma total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） fell clearly（ P 〈 0.05）while high density lipoprotein cholesterol （HDL-C） was improved significantly（ P〈 0.05）;otherwise, insulin, C peptide, blood fat and ISI fell clearly（ P 〈 0.05）. Conclusion Huangqi yuyin recipe can reduce blood glucose significantly and increase the sensitivity of insulin, hence it can significantly improve clinical symptom of insulin resistance and the disturbance of bled fat.