期刊文献+

氟伐他汀短期治疗对冠心病及等危患者高脂餐后血浆甘油三脂C反应蛋白浓度变化的影响

下载PDF
导出
摘要 目的观察氟伐他汀对冠心病及等危患者高脂餐后反应蛋白浓度变化的影响,探讨氟伐他汀短期内对血浆C-反应蛋白(CRP)浓度的影响。方法64例冠心病患者随机分为氟伐他汀组(26例)和常规治疗组(31例),分别在常规治疗的基础上加用氟伐他汀(40mg/d)及安慰剂,治疗前和1周后接受高脂餐负荷试验,检查空腹和餐后4h血浆CRP和血脂水平。结果两组患者餐后的血浆CRP和甘油三酯(TG)水平较空腹时明显升高(P<0.05)。1周后,常规治疗组的空腹和餐后血浆CRP与血脂水平无显著变化;氟伐他汀组的餐后血浆甘油三酯和CRP浓度较治疗前显著降低,但血浆CRP浓度降低与血脂的降低无显著相关。结论短期氟伐他汀治疗能有效降低冠心病及等危患者高脂餐后升高的CRP浓度。
机构地区 桓台县人民医院
出处 《潍坊医学院学报》 2006年第3期225-226,共2页 Acta Academiae Medicinae Weifang
  • 相关文献

参考文献11

  • 1Li JJ,Fang CH.C-reactive is not only an inflammatorymarker but also a direct cause of cardiovascular disease[J].Med Hypotheses,2004,62(6):499~506.
  • 2Li JJ.Silent myocardial ischemia may be releated to inflammatory response[J].Med Hypotheses,2004,62(4):252~256.
  • 3Ridker PM.High-sensitivity C-reactive protein:protential adjunct for global risk assessmentin the primary prevention of cardiovascular disease[J].Circulation,2001,103(11):1813~1818.
  • 4Zahedi RG,Summers LK,Lumb P,et al.The response of serum sialic acid and other acute phase reactants to an oral fat load in healthy humans[J].Eur J Intern Med,2001,12(7):510~514.
  • 5Liu L,Zhao SP,Gao M,et al.Vitamin C preserves endothelial function in patients with coronary heart disease after a high-fat meal[J].Clin Cardiol,2002,25(3):219~224.
  • 6Hyson DA,Paglieroni TG,Wun T,et al.Postprandial lipemia is associated with platelet and monocyte activion and increased monocyte cytokine expression in normolipemic men[J].Clin Appl Thromb Hemost,2002,8(2):147~155.
  • 7Nappo F,Esposito K,Cioffi M,et al.Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients:role of fat and carbohydrate meals[J].J Am Coll Cardiol.2002,39(14):1145~1150.
  • 8Gronholdt ML,Sillesen H,Wiebe BM,et al.Increased acute phase reactants are associatad with levels of lipoproteins and increased carotid plaque volume[J].Eur J Vase Endovasc Surg,2001,21(3):227~234.
  • 9Rifai N,Ridker PM.High-sensitivity C-reactive protein:a novel and promising marker of coronary heart diease[J].Clin Chem,2001,47(6):403~411.
  • 10Plenge JK,Hernandez TL,Weil KM,et al.Simvastatin lownrs Creactive protein within 14 days:an effect independent of low-density lipoprotein cholesterol reduction[J].Circulation,2002,106(16):1447~1452.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部