脑膜瘤性激素受体与病理学特性的关系

Relationship between sex hormone receptors and pathological characteristics in meningioma

目的研究脑膜瘤性激素受体与肿瘤病理学特性之间的关系。方法用细胞免疫组化测定脑膜瘤孕激素受体(PR)和雌激素受体(ER),将测定结果与病理诊断进行比较,研究两者之间的相关性。结果脑膜瘤PR阳性率高于ER阳性率(P<0．01)。PR阳性率良性脑膜瘤83．78％,恶性25％,两者比较差异有统计学意义(P<0．01)。良性脑膜瘤PR阳性强度高。合体细胞型、过渡细胞型和纤维母细胞型脑膜瘤中PR阳性率较高。结论脑膜瘤含有真正的PR;PR表达越低,提示肿瘤有恶性可能,PR可能与脑膜瘤细胞的生长和分化有一定关系。

Objective To study the relationship between sex hormone receptors and pathological characteristics in meningioma. Methods Progesterone receptor（PR） and estrogen receptor（ER） positive cell numbers in meningiomas were detected by cell immunochemistry, and the results were compared with the pathologic diagnosis. Results The positive rate of PR was higher than that of ER in meningiomas（P 〈 0.01）. The positive rate of PR was 83.78% in benign meningiomas and 25% in malignant ones. The difference between the two groups had statistical significance（P 〈 0.01）. The PR positive level intensity were higher in benign meningiomas. The positive rate of PR were higher in syncytial, transitional and fibroblastic meningiomas（P 〈 0.01）. Conclusion The meningioma has genuine PR. The lower PR expression is, the higher the possibility of malignancy is. PR may have certain relations with cell growth and differentiation of meningioma.