期刊文献+

骨髓基质干细胞及其在脑胶质瘤基因治疗中的应用

下载PDF
导出
摘要 骨髓基质干细胞(BMSCs)是近来神经科学领域研究的热点之一。BMSCs来源丰富,转染外源基因后能在体内、外稳定表达,可分泌多种神经营养因子,具有很低的免疫排斥反应,是基因治疗的良好载体,但仍存在一些亟待明确的问题。现主要综述BMSCs部分生物学特性及其作为基因载体治疗胶质瘤的研究现状。
出处 《国际神经病学神经外科学杂志》 2006年第3期242-246,共5页 Journal of International Neurology and Neurosurgery
  • 相关文献

参考文献26

  • 1Jiang Y,Jahagirdar BN,Reinhardt RL,et al.Pluripotency of mesenchymal stem cells derived from adult marrow.Nature,2002,418(6893):41-49.
  • 2Deng W,Obrocka M,Fischer I,et al.In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP.Biochem Biophys Res Commol/Lun,2001,282 (1):148-152.
  • 3Woodbury D,Reynolds K,Black IB.Adult bone marrow stromal stem cells express germline,ectodermal,endodermal,and mesodermal genes prior to neurogenesis.J Neurosci Res,2002,69(6):908-917.
  • 4Rismanchi N,Floyd CL,Berman RF,et al.Cell death and long-term maintenance of neuron-like state after differentiation of rat bone marrow stromal cells:a comparison of protocols.Brain Res,2003,991 (1-2):46-55.
  • 5Kohyama J,Abe H,Shimazaki T,et al.Brain from bone:efficient "meta-differentiation" of marrow stroma-derived mature osteoblasts to neurons with Noggin or a demethylating agent.Differentiation,2001,68 (4 -5):235 -244.
  • 6Jiang Y,Henderson D,Blackstad M,et al.Neuroectodermal differentiation from mouse multipotent adult progenitor cells.Proc Natl Acad Sci U S A,2003,100 Suppl 1:11854-11860.
  • 7Mezey E,Chandross KJ,Harta G,et al.Turning blood into brain:cells bearing neuronal antigens generated in vivo from bone marrow.Science,2000,290(5497):1779-1782.
  • 8Brazelton TR,Rossi FM,Keshet GI,et al.From marrow to brain:expression of neuronal phenotypes in adult mice.Science,2000,290 (5497):1775-1779.
  • 9Lee J,Kuroda S,Shichinohe H,et al.Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice.Neuropathology,2003,23 (3):169-180.
  • 10Nakano K,Migita M,Mochizuki H,et al.Differentiation of transplanted bone marrow cells in the adult mouse brain.Transplantation,2001,71 (12):1735-1740.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部