蝴蝶霜治疗黄褐斑的实验研究

Experimental Study on Chloasma Treated with Butterfly-cream

目的:探讨蝴蝶霜治疗黄褐斑的作用机理。方法:将实验小鼠随机分成治疗组和对照组,测定模型小鼠受试皮肤组织中的超氧化物歧化酶(SOD)活性和过氧化脂质(LPO)及脂褐质和羟脯氨酸的含量,并进行分析。结果:经蝴蝶霜治疗后SOD酶活性和羟脯氨酸含量明显增加,与治疗前比较,具有显著性差异(P<0．01);而小鼠治疗前皮肤组织中LPO和脂褐质含量治疗后明显降低,与治疗前比较,具有显著性差异(P<0．01)。结论:蝴蝶霜能提高局部皮肤组织中SOD酶活性和羟脯氨酸含量,使LPO和脂褐质含量明显降低,消除多余自由基,从而抑制黄褐斑的产生。

Objective： To study the mechanism of Butterfly-cream treating chloasma. Method： Experimental mice were divided randomly into treating group and contrast group, and determine the SOD activity, the quantity of LPO, lipofuscin and oxyproline4-Iydrexyproline （Hyp） in the mice skin, and the experimental results was analyzed. Result： The SOD activity was increased much more and the quantity of Hyyp was more than that of pretreatment after treated with Butterfly-cream, and the treating results had obvious difference between pretreatment and post-treatment（P 〈 0.01 ）. The quantity of LPO and lipofuscin after treated with Butterfly-cream was obviously less than that of pretreatment. Conclusion： Butterfly-cream can increase the SOD activity and the quantity of Hyp, and decrease the quantity of LPO and Lipofuscin, that could dear up superoxidal free radical, so as to restrain chloasma coming into being.