伊班磷酸钠治疗老年恶性肿瘤骨转移的临床研究

Clinical study of Ibandronate in Elder Malignant Tumor Patients with Bone Metastasis

目的评价伊班磷酸钠治疗老年人恶性肿瘤骨转移的临床疗效及安全性。方法采用自身对照的方法,比较19例老年恶性肿瘤骨转移患者,治疗前后血清钙、磷、尿素氮、内生肌酐清除率及骨痛程度、溶骨性病灶的变化。结果治疗后校正血钙有一定程度下降,尿素氮、内生肌酐清除率无明显变化,单次治疗骨痛有效率78.9%。对溶骨性病灶治疗有效率100%,无严重不良反应。结论伊班磷酸钠可有效治疗恶性肿瘤骨转移,不良反应可以耐受。

Objective To evaluate the clinical effects and safety of ibandronate in treatment on elder malignant tumor patients with bone metastases. Methods With the self - control method, compare the concentrations of serum calcium, phosphorus, blood urea nitrogen （BUN） and endogenic creatinine clearance（Ccr） ,bone- pain and the osteolytie loci before treatment and those after treatment with ibandronate. Results After treatment with ibandronate ,the concentrations of serum calcium decrease in some degree and the serum phosphorus decrease transiently. Compare with those before treatment, BUN and Ccr are no significant differences after treatment, the effective rate is 78.9% on bone - pain treatment with ibandronate, and the effective rate is 100% on osteolytic loci treatment with ibandronate. There are no great side effects in treatment with ibandronate. Conclusion Ibandronate can treat malignant tumor with bone metastases effectively and the side effects can be well tolerated.