CCL3L1基因拷贝数与HIV-1易感性

The copy number of CCL3L1 gene and HIV-1 susceptibility

基因因素可影响宿主对HIV的易感性以及艾滋病(AIDS)进程。近来,有研究指出:CCL3L1趋化因子基因拷贝数在基因水平上对HIV感染及艾滋病进程起着重要的决定作用。同一人种中,CCL3L1基因拷贝数低者,HIV_1易感性显著增高,艾滋病进程加快。这项研究提出了一项新的影响HIV_1易感性的重要基因决定因素,并进一步强调了趋化因子系统在HIV感染过程中的重要性———即可以抑制HIV侵入细胞又可以调节抗病毒免疫应答[1]。

Several genetic factors influence HIV-1 susceptibility or AIDS disease progression. A recent study pointed out： copy number of a chemokine gene termed CCL3L1 is relateted with HIV-1 susceptibility and the disease progression. Individuals with low copy numbers of the gene, relative to their ethnic background, were associated with markedly enhanced HIV-1/AIDS susceptibility. These findings define an important new genetic determinant of HIV-1 susceptibility and further emphasize the importance of the chemokine system, either as elements that inhibit HIV-1 infection or that modulate antiviral immtme responses.