1%盐酸布替萘芬乳膏治疗体股癣、足癣疗效观察

Clinical study of butenafine hydrochloride 1% cream in the treatment of tinea pedis,tinea corporis and tineacruris

目的:评价1%盐酸布替萘芬乳膏治疗体股癣、足癣的临床疗效和安全性。方法:采用多中心、随机、双盲、平行对照的方法,试验组外用1%盐酸布替萘芬乳膏,对照组外用1%联苯苄唑乳膏。结果:体股癣患者停药时试验组与对照组痊愈率分别为32.76%和38.98%,有效率分别为93.10%和94.92%;停药2周时,试验组与对照组痊愈率分别为62.07%和64.41%,有效率分别为93.10%和96.61%。足癣患者停药时,试验组与对照组痊愈率分别为29.31%和30.00%,有效率分别为89.66%和85.00%;停药2周时,试验组与对照组痊愈率分别为48.28%和43.33%,有效率分别为91.38%和86.67%。局部不良反应发生率,两试验组为5.13%;两对照组为4.17%。上述各项指标,两组比较差异无统计学意义。结论:1%盐酸布替萘芬乳膏治疗体股癣、足癣安全有效。

Objective:To investigate the efficacy and safety of butenafine hydrochloride 1% cream in the treatment of tinea pedis,tinea cruris and tinea corporis.Methods:A randomized,double-blind,parallel-group trial was used.Results:At the end of study,for tinea cruris and tinea corporis patients,the overall cure rate,the response rates of the test group vs the control group were 32.76% vs 38.98%,93.10% vs 94.92%.Tinea pedis patients were 29.31% vs 30.00%,89.66% vs 85.00%.Two weeks follow-up,for tinea cruris and tinea corporis were 62.07% vs 64.41% and 93.10% vs 96.61%.Tinea pedis patients were 48.28% vs 43.33% and 91.38% vs 86.67%.The local adverse reaction rates of two test groups vs two control groups were 5.13% vs 4.17%.There were no statistically significant differences between two groups on above-mentioned data.Conclusion:Butenafine hydrochloride 1% cream is effective and well-tolerated in the treatment of tinea pedis,tinea cruris and tinea corporis.