肝复乐联合复方丹参治疗慢性肝炎肝硬化疗效观察

Observation On Efficacy of GFL Plus Salvia Miltiorrhiza Injection Combination Therapy on Chronic Hepatits with Liver Cirrhosis

目的探讨肝复乐与复方丹参注射液联合治疗慢性肝炎肝硬化的临床疗效。方法慢性肝炎致肝硬化病人82例,按照随机原则分为两组,对照组单用肝复乐,治疗组肝复乐与复方丹参注射液联用。治疗前后分别检测肝功能ALT、AST、TB、Alb等指标和血清肝纤维化指标透明质酸酶、Ⅲ型前胶原肽、Ⅳ型胶原、层黏蛋白的含量,以及观察症状改善情况。结果治疗组总有效率为95.0%,对照组有效率为72.5%,两组比较差异有显著意义(P<0.05)。肝复乐与复方丹参注射液联合治疗各项指标改善均明显优于对照组,两组比较差异有显著意义。结论肝复乐有疏肝健脾,化瘀软坚之功能,联用复方丹参注射液加强疏通肝内微循环,抗纤维化,改善肝功能,对延缓肝硬化进一步发展具有显著作用。

Objective To evaluate efficacy of GFL （Gan FU Le） plus Salvia Miltiorrhiza Injection （SMI）on chronic hep atits with liver cirrhosis. Methods 82 patients with liver cirrhosis were randomly divided into treatment group and control group.The control group was applied with GFL only,the treatment group was applied to GFL plus SMI, Their liver function and serum marks of hepatic fibrosis were examined before and after treament, and observe effection in ameliorating symptom. Rusults The effective rate in the treatment group and the matched group were 95.0%and 72.5% respectively, with significant difference between the two groups,P〈0.05.Their liver function and serum marks of hepatic fibrosis in treatment group was significantly impoved compared with that in control group,P〈0.05.Conclusion GLF was an effective and safe drug for chronic hepatits with liver cirrhosis. But combined SMI therapy may get better to dredged liver microcirculation, impoved fibrosis and Liver function.They had significant action in delaying liver eirrhosis advanced.