维甲酸对肝硬化患者肝癌发生的干预作用初步观察

Hepatoma prevention effects of retinoic acid on patients with liver cirrhosis

目的观察全反式维甲酸对肝硬化门脉高压行断流术后患者肝癌发生的干预作用。方法41例肝硬化门脉高压手术后患者,随机分为治疗组22例,对照组19例。治疗组口服全反式维甲酸20mg/次,2次/日,连续用药四周以上。进行长期随访,定期检测肝功能、血清γ-GT、AFP,及预后情况。结果实验组疗效好于对照组,但不具有统计学意义(P>0.05)。服药4周时治疗组γ-GT、AFP水平低于对照组,有显著性差异(P<0.05)。结论全反式维甲酸有改善肝硬化患者病情的作用,可能对预防肝硬化患者发生肝癌有一定作用。

Objective To investigate the bepatoma prevention effects of all-trans retinoic acid on patients with liver cirrhosis after peripheral cardial vascular disconnection. Methods 41 patients with liver cirrhosis and portal hypertension were randomized divided into 2 groups after surgery： 22 patients in treated group received all-trans retinoic acid 20mg p.o twice a day for at least 4 weeks and 19 patients in control group received routine treatment only. All patients were followed up, liver function, serum γ -GT and AFP concentration were detected periodically. Results The therapeutic effect of the treated group was better than the control group, but there was no significant difference （P〉0.05）. The level of serum γ -GT and AFP concentration of the treatment groups was lower than the control group significantly after taken the medicine for 4 weeks （P〈0.05）. Conclusion All trans-retinoic acid can improve patient＇s condition of liver cirrhosis, and may play a role in chemoprevention of bepatocellular carcinoma in patient with liver cirrhosis.