通腑逐瘀方对肝硬化患者血浆内毒素及细胞因子的影响

Influence to serum endotoxin and TNF-α,IL-2,IL-10,sIL-2R in cirrhosis patients with the method of Tongfu Zhuyu therapy

目的:探讨通腑逐瘀方对肝硬化患者血浆内毒素及细胞因子的影响。方法:将92例肝硬化患者随机分成中药组和对照组,并分别服用中药通腑逐瘀方和微生态制剂培非康胶囊共30天,采用偶氮显色法检测血浆内毒素,酶联免疫吸附法测定血浆细胞因子TNF-α、IL-10、sIL-2R水平。结果:两组患者治疗后血浆内毒素及TNF-α、sIL-2R水平均有下降。中药组与对照组比较其水平下降更明显(P<0.05)。结论:按通腑逐瘀法组方的中药在降低患者血浆内毒素及TNF-α、sIL-2R水平方面疗效优于培非康胶囊,该法对肝硬化患者肠源性内毒素血症有一定的防治作用。

Objective： To discuss influence to serum endotoxin and TNF-α, IL-2, IL-10, sIL-2R in cirrhosis patients with the method of Tongfu Zhuyu therapy. Mefthods： Ninety-two patients with cirrhosis were enrolled in present study and divided into Chinese medicine treated group and control group, they were treated by the Chinese medicine and PeiFeiKang capsule separately. Serum endotoxin was determined by azo-matrix color reaction; and TNF-α, IL-2, IL-10, sIL-2R were determined by ELISA. Results： The level of serum endotoxin, TNF-α, sIL-2R were too descended in two groups, but they were descended greatly in Chinese medicine treated group than the control group. The level of IL-2 and IL-10 was not changed in two groups. Conclusion： The curative effect of Tongfu Zhuyu therapy is more excellent than PeiFeiKang capsule and the method has certain action in guard against endotoxemia in cirrhosis patients.