固尔苏治疗新生儿肺透明膜病疗效观察

Effects of curosurf on the hyaline membrane disease of the preterm infants

目的探讨固尔苏(肺表面活性物质)治疗新生儿肺透明膜病(HMD)的临床疗效。方法将40例生后确诊为新生儿肺透明膜病行机械通气治疗的患儿随机分为两组:其中20例给予固尔苏治疗(PS组),另正常对照组20例未使用PS(NPS组)。观察治疗前后患儿临床症状及血气,肺氧合指标和呼吸机参数的变化。结果患儿用药前均有不同程度的临床表现,如:紫绀、窒息、呼吸暂停、低氧血症等。用药后PS组均改善缺氧症状,并发症减少,住院时间缩短。NPS组合并颅内出血1例,缺血缺氧性脑病5例,死亡1例。两组比较,有显著差异性(P<0.05);PS组用药后2、6h氧合指标均较用药前明显改善,两组比较,有显著差异性(P<0.05)。结论固尔苏治疗能快速、安全、有效地改善新生儿肺透明膜病患儿的肺功能及临床症状。

Objective To study the effects of Curosurf on the hyaline membrane disease of the preterm infants, Method Totally 40 preterm infants were randomly divided into 2 groups, PS treatment group of 20 cases and negative control group of 20 cases, The changes of blood gas indx, the oxygenization and ventilator parameters after the therapy. Result Before the administration of Curosurf, all cases of the two groups had various degrees of clinical manifestations, such as cyanosis, asphyxia, apnea, hypoxemia, et al. After administration of curosurf, the cases of the treatment group significantly improved their symptoms and signs of hypoxia, cut down the days of hospitalization . While in the control group, 1 cases had intracranial hemorrhage, 5 cases had hypoxic-ischemic encephalopathy, 1 cases died. Significant difference of treatment effectiveness was found between the two groups （ P 〈 0.05 ）. Conclusion Curosurf can rapidly and effectively improve the lung function and clinical symptom of the Hyaline membrane disease of the oreterm infants.