30岁以下乳腺癌102例临床分析

The clinical analysis of breast cancer patients under 30 years of age

目的：探讨30岁以下乳腺癌的临床特点、无瘤生存率和影响预后的因素。方法：回顾性分析我院1989年12月～2000年12月收治的102例30岁以下乳腺癌患者的临床资料，观察患者放射治疗后长期无瘤生存率，分析放射治疗临床特点及影响预后的因素。结果：肿瘤直径≤3cm和〉3cm的患者其3年无瘤生存率分别为91．67％、87．04％（P〈0．01）。腋窝淋巴结转移阴性者3年、5年无瘤生存率分别为92．11％、81．58％，1～3枚阳性者3年、5年无瘤生存率分别为88．24％、70．59％，≥4枚阳性者3年、5年无瘤生存率分别为84．00％、40．00％。放射治疗组3年、5年无瘤生存率分别为94．44％和90．28％，未行放射治疗组3年、5年无瘤生存率分别为76．67％和15．62％（P〈0．01）。COX多因素分析显示，肿瘤大小、腋窝淋巴结转移和是否行放射治疗是影响预后的独立因素。结论：对于30岁以下乳腺癌患者，需早期诊断，早期进行正规的综合治疗，以提高无瘤生存率，降低局部复发率。

Objective： To explore the clinical characteristics, survival and prognosis of breast cancer patients under 30 years. Methods： 102 breast cancer patients under 30 years treated from December 1989 to December 2000 were retrospectively reviewed survival of patients treated with radiotherapy, analyzed clinical features of radiotherapy and prognostic factors. All the date were analyzed by SPLM statistic software. Results： For patients with tumor ≤3 cm and 〉 3 cm,the 3- and 5- year survival rates were 91.67% and 87.04% respectively （P 〈0.01）. For patients with 1-3 positive axillary lymph nodes, the 3- and 5-year surivial rates were 88.24 %, 70.59 %, For patients with 4 and more positive axillary lympth nodes , the 3- and 5-year surivial rates were 84.00% ,40.00%. For patients who had been treated with radiotherapy,the 3- and 5-year surivial rates were 76.07% and 15.62% （P d0.01）. In the multivariate analysis,independent prognostic factors that might influonce the overall surivial. Conclusions： Breast cancer patients aged 30 years and younger may have good prognosis if being diagnosis and being treated by the combined therapy. Its survival rates can be greatly impoved and locoregional recurrence is reduced.