慢性乙型肝炎患者血清TGF-β_1、IL-8和IL-18检测的临床意义

Clinical Significance of Determination of Serum TGF-β_1,IL-8 and IL-18 Levels in Patients with Chronic Hepatitis B

目的:探讨慢性乙型肝炎患者血清TGF-β1、IL-8和IL-18水平的变化。方法:应用放免法和酶免法对42例慢性乙型肝炎患者进行了血清TGF-β1、IL-8和IL-18水平检测,并与35名正常人作比较。结果:慢性乙型肝炎组患者血清TGF-β1、IL-8和IL-18水平均非常显著地高于正常人组(P<0.01),且IL-8、IL-18与TGF-β1呈明显的正相关(r=0.6718,0.6321,P<0.01)。结论:检测慢性乙型肝炎患者血清TGF-β1、IL-8和IL-18水平对疾病的诊断和治疗是一个有用的临床指标。

Objective To explore clinical significance of the changes of serum TGF - β1, IL - 8 and IL - 18 levels in patients with chronic hepatitis B.Methods Serum IL - 8 levels were detected with RIA and TGF -β1, IL - 18 levels we, re detected with ELISA in 42 patients with chronic hepatitis B and 35 controls. Results The levels of serum TGF -β1, IL - 8 and IL- 18 were significantly higher in the patients than those in controls （ P 〈 0.01）. Serum IL - 8, IL - 18 levels were positively correlated with TGF -β1 levels （r =0. 6718, 0. 6321, P 〈 0. 01 ）. Conclusion Detection of serum TGF -β1, IL - 8 and IL - 18 levels might be of prognostic importance in patients with chronic hepatitis B as high levels of these cytokines might favor malignant changes.