肝硬化患者血清sIL-2R和T淋巴细胞亚群水平的探讨

Study on the Changes of Levels of Serum Soluble Interleukin-2 Receptor(sIL-2R) and Distribution Pattern of Peripheral Blood T-Cell Subsets in Patients with Hepatic Cirrhosis

目的:探讨了肝硬化患者血清可溶性白细胞介素-2(sIL-2R)和T淋巴细胞亚群的水平及意义。方法:应用ELISA和单克隆抗体法对54例肝硬化患者进行了血清sIL-2R和T淋巴细胞亚群的测定,并与30名正常健康人作比较。结果:肝硬化患者血清sIL-2R水平非常显著地高于正常人组(P<0.01),经3个月的治疗后血清sIL-2R水平与正常人比较仍有差异(P<0.05),且sIL-2R水平和T淋巴细胞亚群中的CD4/CD8细胞比值密切相关。结论:检测肝硬化患者血清sIL-2R和T淋巴细胞亚群水平可作为患者病情、预后判断的重要检测指标。

Objective To investigate the clinical significance of the changes of seurm sIL -2R levels and T - Cell subset distribution type in patients with hepatic cirrhosis. Methods Serum sIL -2R levels （with ELISA） and peripheral blood T- cell subsets distribution pattern （with monoclonal antibody technique） were determined in 54 patients with hepatic cirrhosis both before and after treatment as well as in 30 controls. Results Before treatment the serum sIL -2R levels were significantly higher in the patients than those in controls （P 〈 0.01 ）, after three months treatment the serum sIL - 2R levels dropped markedly, but still remained significantly higher （P 〈 0.05 ）, and serum sIL - 2R levels were closely related with CD4/CD8 ratio. Conclusion Detection of serum sIL - 2R levels and T - cell subsets ratio is clinically useful in the outcome prediction in patients with hepatic cirrhosis.