阻塞性睡眠呼吸暂停低通气综合征患者血清白介素-6的变化

The changes of serum interleukin -6 in patients with obstructive sleep apnea hypopnea syndrome

目的观察阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清白细胞介素6(IL-6)的变化。方法经过多导生理记录仪(PSG)睡眠呼吸监测把研究对象分为试验组(OSAHS患者65例)、对照组(单纯打鼾者40例),均测量血清IL-6。试验组中32例经鼻持续气道正压通气(nCPAP)治疗,另33例未予nCPAP治疗,2个月后65例都予PSG监测、血清IL-6测量。结果OSAHS患者血清IL-6水平明显高于单纯打鼾者(P<0.05),并与体重指数、整夜睡眠监测中呼吸暂停低通气指数、一整夜睡眠监测中患者脉搏血氧饱和度低于90%时间占整个睡眠监测时间的百分比、匹兹堡睡眠质量指数均有正相关(P<0.05)。nCPAP治疗2个月后血清IL-6水平较治疗前下降(P<0.01),体重指数没有改变(P>0.05)。未予nCPAP治疗组IL-6较前无下降(P>0.05)。结论OSAHS患者血清IL-6水平明显升高,提示此可能与OSAHS患者是心血管事件和糖代谢紊乱发生的高危者有关,经nCPAP治疗能显著降低血清IL-6水平,因而可能降低这些危险性。

Objective To observe the changes of interleurin-6 （IL-6） level in OSAHS patients. Methods Venous blood was collected at 6AM from 65 patients with OSAHS and 40 simple snorers following a full night polysomnography（PSG） test. PSG and serum IL-6 testing were conducted after nasal continuous positive airway pressure （nCPAP） treatment in 32 cases OSAHS patients for 2 months and 33 cases without nCPAP. Results Serum IL-6 level in patients with OSAHS was significantly higher than that of the simple snorers （ P 〈0.05）, Regression analysis revealed that IL-6 level was significantly correlated with BMI, AHI, percentage of time spent when SaO2 〈90% during the whole night sleep and Pittsburg Sleep Quality Index （PSQI） （ P 〈0.05） in OSAHS patients. In addition,after two months of nCPAP therapy, levels of IL-6 was significantly decreased in OSAHS grouip （ P 〈0.01）. Conclusions Serum IL-6 level insrease in patients with OSAHS. It is suggested that elevated level of IL-6 might play an important role in the development of coronary heart disease and glucose metabolic disorder in patients with OSAHS, and nCPAP therapy could induce the decrease of IL-6 level, therefore may be decreased the risk of such morbidities.