L-扁桃酸金属配位分子烙印聚合物的手性分离能力

Chiral Separation Ability of Metal-Complexing Imprinted Polymer for L-mandelic Acid

以CuⅡ-[N-（4-vinylbenzyl）]iminodiacetic acid为功能单体、三甲氧基丙烷三甲基丙烯酸酯为交联剂、甲醇为聚合溶剂,制备了L-扁桃酸的金属配位分子烙印聚合物.用它作为色谱固定相,系统考察了流动相的pH、甲醇含量以及缓冲溶液的浓度对其手性分离能力的影响.在中性或弱碱性（pH 7～9）流动相条件下,L-扁桃酸的金属配位分子烙印聚合物对D,L-扁桃酸的手性分离效果最好;其手性分离能力随流动相中甲醇含量和缓冲溶液浓度的增大而增强.本研究的工作为在极性溶剂中制备高选择性的分子烙印聚合物提供了实践支持.

Metal-complexing imprinted polymer for L-mandelic acid was prepared using Cu （ Ⅱ ）-[ No（4- vinylbenzyl） ] iminodiacetic acid as functional monomer, trimethylolpropane trimethacrylate as crosslinker and methanol as porogenic agent. Chiral separation ability of metal-complexing imprinted polymer to D,L-mandelic acid was investigated by high performance liquid chromatography. The mobile phase conditions （ pH, methanol content, buffer concentration, etc. ） could significantly influence the chiral separation ability of metal-oomplexing imprinted polymer. Highly chiral selective to the template molecule by metal-complexing imprinted polymer was achieved as pH 7 -9 of the mobile phase; the chiral separation ability of metal-complexing imprinted polymer was increased with the increase of methanol content and buffer concentration. It is suggested the feasibility to prepare highly selective molecularly imprinted polymer in polar solvent.