术中应用6%羟乙基淀粉(200/0.5)氯化钠注射液对患者血液循环的影响

The Efficacy research of 6% hydroxyethyl starch(200/0.5) for expand plasma volume during operation

目的观察6%羟乙基淀粉（200/0.5）氯化钠注射液用于术中扩充血容量的临床效果.方法144例择期手术患者,ASAⅠ～Ⅱ级,随机分为试验组（6%羟乙基淀粉）和对照组（HES）各72例.容量治疗后观察两组血流动力学、血液流变学的变化.结果组间术中血流动力学、血液流变学指标差异均无统计学意义（P＞0.05）.结论6%羟乙基淀粉（200/0.5）氯化钠注射液用于临床扩容及血液稀释是有效的.

Objective To evaluate the efficacy of 6% hydroxyethyl starch（200/0.5） for expanding plasma volume during operation. Methods Multiple centers, randomized and double blind procedure was conducted. 144 adult patients, ASA grade Ⅰ -Ⅱ , were scheduled for selective surgery. Both the trial group（6% hydroxyethyl starch group）and the control group（HES group） included 72 patients each. The hemedynamics and hemorheology were observed after administration. Results There were no significant differences in haemodynamics and hemorheology between the trial group and the control group（ P 〉 0.05）. Conclusion 6% hydmxyethyl starch （200/0.5） is effective for expanding plasma volume during operation.