宫颈泰栓药效学研究

Research of Supp. Gongjingtai on pharmacodynamics

目的观察宫颈泰栓的收敛、抗炎、抗菌作用．方法取新鲜蛋清液，豚鼠直肠和皮肤，观察宫颈泰栓的收敛作用；取体重２５～３０ｇ健康小鼠１２０只，随机分为６组，观察宫颈泰栓对二甲苯造成鼠耳炎症反应的影响；取１４０～１６５ｇ健康大鼠如只，随机分为９组．观察宫颈泰枪对滤纸片到成肉芽肿模型的影响；用平皿法和试管法观察宫颈泰栓对金葡菌、大肠杆菌、绿脓杆茵、链球菌、白色念珠菌等细菌的抗菌作用．结果宫颈泰栓（或粉）可使蛋清液沉淀．使豚鼠肠粘膜和皮肤变白、紧缩等；对二甲苯造成鼠耳炎症反应有明显抑制作用；对小鼠尾部绿脓杆菌感染有明显保护作用；对金葡菌、链球菌、大肠杆菌、绿脓杆茵、白色念球菌均有明显抑菌作用。结论宫颈泰栓有明显收敛、抗炎、抗菌作用，是治疗宫颈糜烂较理想的药物．

Objective To observe the effects of Gongjingtai suppository on astringency,anti-inflammation and antibioses.Methods Fresh egg albumen, guinea pig rectum and skin were used to observe the astringent action of Gongjingtai. One hundred and twenty healthy pedigree Kunming mice (25～30g) were divided into six groups randomly to observe the efect of gongingtai on mice ear inflammation indused by xylene. Ninety healthy Wistar rats (140～ 1659) were divided into nine groups randomly to observe the effect of gongjingtai on granuloma model induced by filter paper dice. Disc method and test tube method were used to observe the antibacterial effects of Gongjingtai on S. aureus, E. coli, Ps. aeruginosa,Streptococcus, Candida albicans and so on.Results Gongjingtai can cause egg albumen sedimentary, rectum mucosa and skin pale and constrictive, significantly inhibit the mice ear inflammation and protect mice tail from being infected with Ps. aeruginosa, and has obvious antibacterial effects on S. aureus,Streptococcus, E. coli, Ps. aeruginosa,Candida albicans and soon.